What is Testosterone
Replacement Therapy (TRT)?

Have you been diagnosed with or suspect low testosterone?

What is Testosterone Replacement Therapy (TRT)?

TRT is a commonly used treatment for low testosterone in men with diagnosed hypogonadism (low-T) due to certain medical conditions.

What is hypogonadism?

Testosterone deficiency is a clinical syndrome resulting from insufficient secretion of testosterone due to primary or secondary hypogonadism.

How is hypogonadism diagnosed?

Only a fraction of men with low testosterone are tested, but for those that are, your doctor will diagnose hypogonadism through laboratory testing and assessment of symptoms. Hypogonadism is present when blood tests drawn on at least two separate occasions in the morning, show total testosterone levels less than 300 ng/dL.

39% of men aged >45 have low testosterone1
<4% of adult men receive a serum testosterone test

1 Mulligan T, Frick MF, Zuraw QC, Stemhagen A, McWhirter C. Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Int J Clin Pract. 2006;60(7):762-769. doi:10.1111/j.1742-1241.2006.01092.x. PMCID: PMC1569444

2 Malik, R.D., Lapin, B., Wang, C.E., Lakeman, J.C., & Helfand, B.T. (2015). Are we testing appropriately for low testosterone? Characterization of tested men and compliance with current guidelines. The Journal of Sexual Medicine, 12(1), 66–75. https://doi.org/10.1111/jsm.12730

Talk about your TRT options

Men with low testosterone levels can explore several routes to TRT drug administration, including oral, pellet, topical/transdermal, injection, and intranasal methods.

Ask your doctor for more information to find out what is right for you.

The oral formulation of testosterone taken by mouth.

Subcutaneous (under your skin) and Intramuscular (into your muscle) injections offer long-acting and short-acting forms of TRT. Injections can be administered weekly, biweekly or monthly.

Product formulations include topical liquids, gels and patches that deliver testosterone directly through your skin when applied daily.

This formulation of testosterone is administered by placing the pellet under the skin of your buttocks or upper hip, under local anesthesia.

This method of administration comes in the form of a gel and is administered through your nose.

TRT ADMINISTRATION METHODS

Explore the features of each formulation

Subcutaneous Injection
Intramuscular Injection
Oral pills
Topical or transdermal
Pellets
Intranasal
Mode of administration
Subcutaneous injection (under the skin)
Intramuscular needle (into the muscle)
Oral formulation taken by mouth
Topical
Administered by placing the pellet under the skin of the buttocks or upper hip under local anaesthesia
This method of administration comes in the form of a gel and is applied to the inside of the nose
Setting of administration
Self-administered at home
Administered at home or doctor’s office
Self-administered at home
Self-administered at home
Administered at the doctor’s office
Self-administered at home
Frequency of 
administration
Weekly
Weekly, biweekly, 
or monthly
Twice daily
Daily
Replaced every three to six months
Usually three times a day in each nostril
Device 
preparation
Ready-to-use application
Needle and vial syringe preparation
Not required
Not required
Not required – administer at doctor’s office
Pump priming before first-time use
Administration / application  experience
Virtually pain-free injection1*†

*150 hypogonadal male patients entered the study.


†Injection site reaction, including injection site bruising, injection site haemorrhage, injection site erythema and injection site induration were reported in 12.7% of clinical trial patients who received XYOSTED for up to one year. No patients discontinued XYOSTED because of injection site reactions.
Some degree of injection pain that varies with patient
Ingested
Applied daily to the skin and patient must avoid transferring the medication to others by contact
Some degree of pain at insertion site
Nasal pump

These are not a complete description of each type of product or instructions for their use. Follow your doctor's directions and review the instructions for any product that you use.

TRT = Testosterone Replacement Therapy

1Data on File. XYO-0008. Antares Pharma, Inc.

 

Why is it important to take your Testosterone Replacement Therapy (TRT) as prescribed?


It is important to take TRT at the recommended frequency, as prescribed by your doctor. 
They will check your testosterone levels after 6 weeks, then at regular periods to make sure you are on the correct dose of TRT, and that it is working as it should for you.


Speak to your doctor about your journey today.

Learn More


INDICATION/WHAT IS XYOSTED?

XYOSTED is a prescription medicine that contains testosterone. XYOSTED is used to treat adult men who have low or no testosterone due to certain medical conditions.

It is not known if XYOSTED is safe and effective for use in children younger than 18 years old. Improper use of XYOSTED may affect bone growth in children.

It is not known if XYOSTED is safe or effective to treat men who have low testosterone due to aging.

XYOSTED is a controlled substance (CIII) because it contains testosterone that can be a target for people who abuse prescription medicines. Keep your XYOSTED in a safe place to protect it. Never give your XYOSTED to anyone else. Selling or giving away this medicine may harm others and it is against the law.

XYOSTED is not meant for use by women.

IMPORTANT SAFETY INFORMATION

Do not use XYOSTED if you:

  • Are a man who has breast cancer.
  • Have or might have prostate cancer.
  • Are a woman who is pregnant. XYOSTED may harm your unborn baby.
  • Are allergic to XYOSTED or to any ingredients in XYOSTED including testosterone or sesame oil.

What should I tell my healthcare provider before using XYOSTED?

Before you use XYOSTED, tell your healthcare provider about all of your medical conditions, including, if you have any of the following: high blood pressure or are being treated for high blood pressure, or have heart problems, high red blood cell count, urinary problems due to an enlarged prostate, kidney or liver problems, a history of mental health illness including suicidal thoughts or actions, depression, anxiety or mood disorder, or problems breathing while you sleep (sleep apnea).

Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Using XYOSTED with other medicines can affect each other. Especially, tell your healthcare provider if you take insulin, medicines that decrease blood clotting (blood thinners), corticosteroids or medicines for pain and cold. Know the medicines you take. Ask your pharmacist for a list of all your medicines if you are not sure. Show your list to your healthcare provider and pharmacist when you get a new medicine.

How should I use XYOSTED?

  • See the detailed Instructions for Use for Information about how to use XYOSTED.
  • Use XYOSTED exactly as your healthcare provider tells you to take it.
  • Your healthcare provider will show you or your caregiver how to inject XYOSTED. You should not inject XYOSTED until you have been trained on the proper way to use it.

What are the possible side effects of XYOSTED?

XYOSTED can cause serious side effects including:

  • Increase in red blood cell count, hematocrit or hemoglobin. High red blood cell counts increase the risk of clots, strokes, and heart attacks. You may need to stop XYOSTED if your red blood cell count increases. Your healthcare provider should check your red blood cell count, hematocrit and hemoglobin while you use XYOSTED.
  • If you already have an enlarged prostate, your signs and symptoms may get worse while using XYOSTED. This can include: increased nighttime urination, trouble starting urination, more frequent urination, feeling an urge to urinate, having a urine accident, and being unable to pass urine or weak urine flow
  • Increased risk of prostate cancer. Your healthcare provider should check you for prostate cancer or any other prostate problems before you start and while you use XYOSTED.
  • Blood clots in the legs or lungs. Signs and symptoms of a blood clot in your leg can include leg pain, swelling or redness. Signs and symptoms of a blood clot in your lungs can include difficulty breathing or chest pain.
  • Increase in blood pressure. XYOSTED can increase your blood pressure. Increases in blood pressure can increase the risk of heart attack or stroke over time. If your blood pressure increases while on XYOSTED, blood pressure medicines may need to be started. If you are taking blood pressure medicines, new blood pressure medicines may need to be added or your current blood pressure medicines may need to be adjusted to control your blood pressure. If your blood pressure cannot be controlled, XYOSTED may need to be stopped. Your healthcare provider will monitor your blood pressure while you are being treated with XYOSTED.
  • Abuse. Testosterone can be abused, when taken at higher than prescribed doses and when used with other anabolic androgenic steroids. Abuse can cause serious heart and psychological side effects.
  • In large doses XYOSTED may lower your sperm count.
  • Liver problems. Symptoms of liver problems may include nausea or vomiting, yellowing of your skin or whites of your eyes, dark urine or pain on the right side of your stomach area (abdominal pain).
  • Swelling of your ankles, feet, or body, with or without heart failure. This may cause serious problems for people who have heart, kidney or liver disease.
  • Enlarged or painful breasts.
  • Problems breathing while you sleep (sleep apnea).
  • Change in mood. Talk to your healthcare provider if you have changes in mood or behavior including, new or worsening depression, or suicidal thoughts.

Call your healthcare provider right away if you have any of the serious side effects listed above.

The most common side effects of XYOSTED include: red blood cell increase, prostatic specific antigen (PSA) increase (a blood test for prostate cancer), increased blood pressure, and injection site reactions including bruising, bleeding, redness and headache.

Other side effects include more erections than are normal for you or erections that last a long time. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of XYOSTED. For more information, ask your healthcare provider or pharmacist.

For more information, go to www.XYOSTED.com
or call 1-844-XYOSTED (1-844-996-7833).
To report side effects to the FDA,
visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see the full Prescribing Information and Medication Guide.
April 2025 Update.