XYOSTED is a prescription medicine used to treat adult men who have low or no testosterone due to certain medical conditions. It is not known if XYOSTED is safe and effective for use in children younger than 18 years old or for the treatment of men who have low testosterone due to aging. Improper use of XYOSTED may affect bone growth in children.

Your doctor will diagnose hypogonadism based on a combination of your symptoms and laboratory testing. A diagnosis of low testosterone is typically confirmed by at least two separate early morning blood tests showing total testosterone levels below 300 ng/dL.

In a clinical study of 150 patients on XYOSTED*, 90% had testosterone levels in the normal range† by week 12. Individual results may vary.

* Studied for 52 weeks when taken every week as directed. Achieving desired blood levels may require dose adjustments at Week 7 based upon Week 6 blood levels. 
Some patients fell below minimum level of 300ng/dL despite dose adjustments.

† “Normal Range” is defined as 300-1,100 ng/dL.

XYOSTED is a once-weekly auto-injector used to deliver testosterone subcutaneously. It is designed to be virtually painless.1*† Your healthcare provider will train you on how to use it properly. For additional resources please see ‘Instructions for Use’ and the ‘How To Take XYOSTED’ video.

* 150 patients entered the one-year trial; 99.4% of injections were reported to be pain free.

† Injection site reactions, including bruising, bleeding, redness, and hardness, were reported in 12.7% of patients who received XYOSTED for up to 1 year in the trial. 
No patients discontinued XYOSTED because of injection site reactions.

1 Data on file. XYO-0008. Antares Pharma, Inc.

The most common side effects are increased hematocrit, hypertension, increased PSA, injection site bruising, headaches, back pain, increased blood creatine phosphokinase, and injection site hemorrhage, each of which occurred in fewer than 15% of participants in two clinical studies in a total of 283 men who received XYOSTED once a week for up to one year. 


Please refer to the Important Safety Information for full Warnings and Precautions.

In a one-year clinical trial of 150 men receiving 1,519 injections, 99.4% of injections were reported as painless.1 Injection site reactions can occur, including: bruising, bleeding, redness, and hardness.

The needle in the XYOSTED auto-injector is not visible before or during injection. The device is designed to be user-friendly and discreet, with a collar-activated mechanism that hides the needle.

Store XYOSTED at room temperature (68°F to 77°F or 20°C to 25°C). Do not refrigerate or freeze. Keep it in the original packaging to protect it from light and out of reach of children.

Yes, you can travel with XYOSTED.* Be sure to pack it in your carry-on luggage if you’re flying. You may also want to bring a copy of your prescription and a letter from your doctor to help with airport security.

* Store XYOSTED at room temperature (68°F to 77°F or 20°C to 25°C). Do not refrigerate or freeze. Keep it in the original packaging to protect it from light and out of reach of children.

Yes. Most eligible* commercially insured patients will pay as little as $25 out of pocket for their XYOSTED each time a prescription is filled. This offer is valid for 13 prescription fills per year. Certain eligibility restrictions apply. You can sign up at www.XYOSTED.com/copay

* Eligibility restrictions: Offer not valid for prescriptions reimbursed under any federal or state healthcare program, including Medicare, Medicaid, or any state medical assistance programs. Offer void where prohibited by law, taxed, or restricted. Offer only valid in the USA. Maximum benefit up to $125 for each prescription filled. Halozyme reserves the right to rescind, revoke, or amend this offer at any time without notice. By using this co-pay card, you demonstrate that you understand and agree to comply with the terms and conditions of this offer as put forth on this co-pay assistance card.

You will need to contact your insurance provider to find out if you are covered.

If your insurance does not cover XYOSTED, you may still be able to access XYOSTED through the XYOSTED4YOU Cash Program. This program is designed to help eligible* patients - whether uninsured or denied coverage - to purchase XYOSTED for $199 per month with a valid prescription.

* Eligibility restrictions: Must be 18 years or over with a valid prescription for XYOSTED® (testosterone enanthate). Must be a U.S. resident with a valid U.S. shipping address. Additional shipping charges may apply. Offer not valid for prescriptions reimbursed under any private insurance or any federal or state healthcare program, including, but not limited to, Medicare, Medicaid, Tricare, or any state medical assistance programs. Purchases made under this program cannot be claimed in any Part D True Out of Pocket Cost (TrOOP) Submission. Patients are responsible for reporting use of this program to any private insurer, health plan or third-party payer. The XYOSTED4YOU Cash Program is not health insurance. Cannot be combined with other offers or programs. Offer void where prohibited by law, taxed, or restricted. Halozyme reserves the right to rescind, revoke, or amend this offer at any time without notice. By enrolling in this program, you demonstrate that you understand and agree to comply with the terms and conditions set forth herein and any additional Terms and Conditions set for by Sterling Pharmacy regarding purchases made under this program.

To participate, you must:

• Be 18 years or older
• Have a valid prescription for XYOSTED
• Be a U.S. resident with a valid U.S. shipping address

Please note: This program is not insurance and cannot be used in combination with any federal or state healthcare programs (like Medicare or Medicaid). 
Additional terms and conditions apply.

You can obtain XYOSTED through one of the program’s partnered specialty pharmacies:

National Specialty Pharmacy 

Sterling Specialty Pharmacy.
Call 1-888-618-4126

Local Specialty Pharmacies 

Yes. XYOSTED is available for home delivery through our trusted specialty pharmacy partners. To get started, simply ask your doctor to send your prescription to any one of the specialty pharmacy partners listed below.

National Specialty Pharmacy

Sterling Specialty Pharmacy:
Call 1-888-618-4126

Regional Specialty Pharmacies